Search results for "fusion [photon photon]"
showing 10 items of 724 documents
Identification of blanket design points using an integrated multi-physics approach
2017
Abstract The breeding blanket (BB) is one of the key components for a fusion reactor. It is expected to sustain and remove considerable heat loads due to the heat flux coming from the plasma and the nuclear power deposited by the fusion neutrons. In the design of the BB, the engineering requirements of nuclear, material and safety kind are involved. In the European DEMO project, several efforts are dedicated to the development of an integrated simulation-design tool able to perform a multi-physics analysis, allowing the characterisation of BB design points which are consistent from the neutronic, thermal-hydraulic and thermo-mechanical point of view. Furthermore, at Karlsruhe Institute of T…
Structural assessment of a whole toroidal sector of the HELIAS 5-B breeding blanket
2021
Abstract The European roadmap for the realization of fusion energy considers the stellarator line as a possible long-term alternative to a tokamak DEMO. In this context, from the plasma physics standpoint, the most promising option is a five-field period power plant called HELIcal-axis Advanced Stellarator (HELIAS) 5-B. In order to allow the electricity production, the HELIAS 5-B reactor must be endowed with a breeding blanket (BB). Hence, in this paper, the advancements in the HELIAS 5-B BB design are reported. In particular, the structural assessment of a whole BB period, extending along toroidal direction for 72 °, is depicted. A geometric configuration encompassing dummy BB segments has…
Preliminary structural assessment of the HELIAS 5-B breeding blanket
2019
Abstract The European Roadmap to the realisation of fusion energy, carried out by the EUROfusion consortium, considers the stellarator concept as a possible long-term alternative to a tokamak fusion power plant. To this purpose a pivotal issue is the design of a HELIcal-axis Advanced Stellarator (HELIAS) machine equipped with a tritium Breeding Blanket (BB), considering the achievements and the design experience acquired in the pre-conceptual design phase of the tokamak DEMO BB. Therefore, within the framework of EUROfusion Work Package S2 R&D activity, a research campaign has been launched at KIT. The scope of the research has been the determination of a preliminary BB segmentation scheme …
Validation of Multi-Physics Integrated Procedure for the HCPB Breeding Blanket
2019
The wide range of requirements and constraints involved in the design of nuclear components for fusion reactors makes the development of multi-physics analysis procedures of utmost importance. In the framework of the European DEMO project, the Karlsruhe Institute of Technology (KIT) is dedicating several efforts to the development of a multi-physics analysis tool allowing the characterization of breeding blanket design points which are consistent from the neutronic, thermal-hydraulic and thermal-mechanical points of view. In particular, a procedure developed at KIT is characterized by the implementation of analysis software only. A preliminary step for the validation of such a procedure ha…
Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity.
2002
Member 4 of human solute carrier family 7 (SLC7A4) exhibits significant sequence homology with the SLC7 subfamily of human cationic amino acid transporters (hCATs) [Sperandeo, Borsani, Incerti, Zollo, Rossi, Zuffardi, Castaldo, Taglialatela, Andria and Sebastio (1998) Genomics 49, 230–236]. It is therefore often referred to as hCAT-4 even though no convincing transport activity has been shown for this protein. We expressed SLC7A4 in Xenopus laevis oocytes, but could not detect any transport activity for cationic, neutral or anionic amino acids or for the polyamine putrescine. In addition, human glioblastoma cells stably overexpressing a fusion protein between SLC7A4 and the enhanced green f…
Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane
2005
We have previously shown that activation of PKC (protein kinase C) results in internalization of hCAT-1 [human CAT-1 (cationic amino acid transporter 1)] and a decrease in arginine transport [Rotmann, Strand, Martiné and Closs (2004) J. Biol. Chem. 279, 54185–54192]. However, others found increased transport rates for arginine in response to PKC activation, suggesting a differential effect of PKC on different CAT isoforms. Therefore we investigated the effect of PKC on hCAT-3, an isoform expressed in thymus, brain, ovary, uterus and mammary gland. In Xenopus laevis oocytes and human U373MG glioblastoma cells, hCAT-3-mediated L-arginine transport was significantly reduced upon treatment with…
L’innovazione tecnologica e il Faculty Development.
2023
La crisi pandemica ha accelerato la diffusione di ambienti di apprendimento caratterizzati dall'uso intensivo della tecnologia. Questa novità rappresenta un obiettivo trasversale della professionalizzazione del docente universitario, con una particolare declinazione sul versante pedagogico-didattico-valutativo quale questione strategica per lo sviluppo dell’alta formazione. Il contributo illustra i risultati di una ricerca condotta con 119 docenti universitari neoassunti e 20 Direttori di dipartimento. La finalità della ricerca è stata, da una parte, rilevare la percezione dei docenti neoassunti relativa alle proprie competenze didattiche, metacognitive e valutative, con riferimento alla di…
The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.
1999
Interleukin-6 (IL-6) triggers pivotal pathways in vivo. The designer protein hyper-IL-6 (H-IL-6) fuses the soluble IL-6 receptor (sIL-6R) through an intermediate linker with IL-6. The intracellular pathways that are triggered by H-IL-6 are not defined yet. Therefore, we studied the molecular mechanisms leading to H-IL-6-dependent gene activation. H-IL-6 stimulates haptoglobin mRNA expression in HepG2 cells, which is transcriptionally mediated as assessed by run-off experiments. The increase in haptoglobin gene transcription correlates with higher nuclear translocation of tyrosine-phosphorylated STAT3 and its DNA binding. As H-IL-6 stimulates STAT3-dependent gene transcription, we compared t…
Experimental tests on Li-ceramic breeders for the helium cooled pebble bed (HCPB) blanket design
2003
The Helium Cooled Pebble Bed (HCPB) Test Blanket Module (TBM) to be tested in ITER (International Thermonuclear Experimental Reactor) Reactor foresees the utilization of Lithiate ceramics as Tritium breeder in form of pebble beds. Since 1998, ENEA has launched many experimental activities for the evaluation of the breeder thermomechanics and the interaction between the pebble beds and the prismatic steel containment walls. Main objectives of these activities are the measurement of the pebble bed effective thermal conductivity, the wall heat transfer coefficient, the pressure loads and deformations on the lateral walls and their dependency from the mechanical constraints. The paper presents …
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
2003
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in c-Jun is essential for signal-dependent target gene activation. We show that c-Jun phosphorylation mediates dissociation of an inhibitory complex, which is associated with histone deacetylase 3 (HDAC3). The subsequent events that ultimately cause increased mRNA synthesis are independent of c-Jun phosphorylation and its interaction with JNK. These findings provide an 'activation by de-repression' model as an explanation for the stimulatory function of JNK on c-Jun.